Abstract Search

ea0025oc4.8 | Bone and diabetes | SFEBES2011

Hyperghrelinaemia, hyperphagia, food hoarding and reduced adiposity in an imprinting centre deletion mouse model of Prader–Willi syndrome

Wells Timothy , Relkovic Dinko , Furby Hannah , Guschina Irina , Nishimura Sachiko , Resnick James , Isles Anthony

PraderWilli syndrome (PWS) is a neurodevelopmental disorder caused by a lack of paternal gene expression from 15q11q13 and is characterised by failure to thrive in infancy, followed by hyperphagia due to abnormal satiety responses and increased motivation by food. We investigated growth and metabolism a mouse model in which the imprinting centre (IC) of the homologous PWS interval has been deleted (PWS-IC mice). Growth retardation only emerged post-natally, with ad...

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ea0034p218 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Young women with polycystic ovary syndrome have increased concentrations of circulating annexin V-positive microparticles derived predominantly from platelets

Willis Gareth , Connolly Katherine , Ladell Kristin , Miners Kelly , Price David , Guschina Irina , Clayton Aled , James Philip , Rees Aled

Background: Women with polycystic ovary syndrome (PCOS) may have increased cardiovascular (CV) risk but the mechanisms are unclear. Microparticles (MP), small circulating vesicles released from platelets, monocytes and endothelial cells, are elevated in patients with CV disease, and may increase CV risk through altered cell content and/or increased surface exposure of procoagulant phosphatidylserine (PS).Aims: To compare MP characteristics between women ...

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Endocrine Abstracts

Hyperghrelinaemia, hyperphagia, food hoarding and reduced adiposity in an imprinting centre deletion mouse model of Prader–Willi syndrome

Young women with polycystic ovary syndrome have increased concentrations of circulating annexin V-positive microparticles derived predominantly from platelets

BiosciAbstracts